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Image Search Results
Journal: Heliyon
Article Title: Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study
doi: 10.1016/j.heliyon.2023.e21616
Figure Lengend Snippet: Associated co-expressed differential proteins in placenta and plasma among pregnant women with ICP and healthy pregnant women.
Article Snippet: The primary antibodies used in this study were anti -NECTIN1 (1:100 dilution, Cat. 24713-1-AP, ProteinTech), anti -SPINT1 (1:100 dilution, Cat. ab189511; Abcam), anti -
Techniques: Clinical Proteomics, Protease Inhibitor
Journal: Heliyon
Article Title: Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study
doi: 10.1016/j.heliyon.2023.e21616
Figure Lengend Snippet: Correlation analysis of co-differentially expressed protein levels between placental and plasma samples. (A) Correlation analysis of RPS7 between placental and plasma samples. (B) Correlation analysis of NECTIN3 between placental and plasma samples. (C) Correlation analysis of NECTIN1 between placental and plasma samples. (D) Correlation analysis of SPINT1 between placental and plasma samples. (E) Correlation analysis of SERPINA7 between placental and plasma samples. (F) Correlation analysis of CD320 between placental and plasma samples. (G) Correlation analysis of ITIH3 between placental and plasma samples. (H) Correlation analysis of ENPP2 between placental and plasma samples. (I) Correlation analysis of SERPIND1 between placental and plasma samples.
Article Snippet: The primary antibodies used in this study were anti -NECTIN1 (1:100 dilution, Cat. 24713-1-AP, ProteinTech), anti -SPINT1 (1:100 dilution, Cat. ab189511; Abcam), anti -
Techniques: Clinical Proteomics
Journal: Heliyon
Article Title: Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study
doi: 10.1016/j.heliyon.2023.e21616
Figure Lengend Snippet: Correlation analysis between ELISA and sequencing results and the validation of plasma differential proteins using ELISA. (A–E) The correlation analysis of SPINT1, SERPINA7, NECTIN1, SERPIND1, and ITIH3 between ELISA and sequencing results. (F) NECTIN1 levels in plasma samples obtained from ICP and control groups (P < 0.0001). (G) SPINT1 levels in plasma samples obtained from ICP and control groups (P < 0.0001). (H) ITIH3 levels in plasma samples obtained from ICP and control groups (P = 0.0001). (I) ENPP2 levels in plasma samples obtained from ICP and control groups (P < 0.0001). (J) SERPIND1 levels in plasma samples obtained from ICP and control groups (P < 0.0001); (****P < 0.0001, ***P < 0.001). ELISA, enzyme-linked immunosorbent assay; ICP, intrahepatic cholestasis of pregnancy.
Article Snippet: The primary antibodies used in this study were anti -NECTIN1 (1:100 dilution, Cat. 24713-1-AP, ProteinTech), anti -SPINT1 (1:100 dilution, Cat. ab189511; Abcam), anti -
Techniques: Enzyme-linked Immunosorbent Assay, Sequencing, Biomarker Discovery, Clinical Proteomics, Control
Journal: Heliyon
Article Title: Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study
doi: 10.1016/j.heliyon.2023.e21616
Figure Lengend Snippet: Diagnostic value analysis of plasma proteins in ICP.
Article Snippet: The primary antibodies used in this study were anti -NECTIN1 (1:100 dilution, Cat. 24713-1-AP, ProteinTech), anti -SPINT1 (1:100 dilution, Cat. ab189511; Abcam), anti -
Techniques: Diagnostic Assay, Clinical Proteomics
Journal: Scientific Reports
Article Title: The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice
doi: 10.1038/s41598-022-15151-4
Figure Lengend Snippet: Phenotypes of Slc26a7 −/− and Slc26a4 −/− mice on a low iodine diet. ( a ) Urine iodine levels of female Slc26a7 +/− mice with normal and low iodine diets; n = 6 mice in each group. ** p < 0.01 determined by Student’s t test. ( b ) Growth curve of male wild type (WT), Slc26a7 +/− , Slc26a7 −/− , and Slc26a7 −/− mice receiving l -thyroxine (L-T4) replacement from day 21 with a low iodine diet. Note that Slc26a7 −/− mice without thyroid hormone replacement did not survive. ( c ) Serum free thyroxine (FT4) levels in male WT, Slc26a7 +/− , and Slc26a7 −/− mice with normal and low iodine diet at day 21; n = 4–5 mice of each genotype. Two-way analysis of variance (ANOVA) showed significant effects of genotype ( F (2, 20) = 29.92, p < 0.0001). ** p < 0.01, *** p < 0.001 determined by Tukey’s test compared with WT mice with same diet. ( d ) Serum FT4 levels in male WT, Slc26a4 +/− , and Slc26a4 −/− mice that were fed a low iodine diet, at day 90; n = 4–5 mice of each genotype. One-way ANOVA showed no significant differences among the three groups ( F (2, 10) = 0.19, p = 0.83). WT wild type, L-T4 l -thyroxine, FT4 free thyroxine.
Article Snippet: Thyroid hormone replacement with albuminized drinking water containing 0.39
Techniques: